BRUNEOMYCIN

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1.What is the BRUNEOMYCIN ?

Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).

2.What is the CAS number for BRUNEOMYCIN ?

The CAS number of BRUNEOMYCIN is 3930-19-6.

More information of BRUNEOMYCIN 3930-19-6 are:

3.What are another words for BRUNEOMYCIN ?

Synonyms?for?BRUNEOMYCIN 3930-19-6:Picolinicacid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-(7CI,8CI); (R)-Streptonigrin;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinicacid; 5278RP; AO 50165L302; Abbott Crystalline antibiotic; Bruneomycin; NSC45383; NSC 56748; NSC 83950; Nigrin; Rufocromomycin; SN; STP; Streptonigran;Streptonigrin

4.What is the molecular formula of BRUNEOMYCIN?

The chemical formula of ?BRUNEOMYCIN is?C25H22 N4 O8 which containing 25 Carbon atoms,22 Hydrogen atoms,4 Nitrogen atoms and 8 Oxygen atoms,and the molecular weight of??BRUNEOMYCIN?is 506.51.

5.What is BRUNEOMYCIN (3930-19-6) used for?

Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities. Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner. It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml. Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine and orthophenanthroline. Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed. Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner. In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.

InChI:InChI=1/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)

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6.Buy BRUNEOMYCIN with the best price .

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